Nuclear Medicine In Pharmaceutical Research

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Nuclear Medicine In Pharmaceutical Research


Nuclear Medicine In Pharmaceutical Research
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Nuclear Medicine In Pharmaceutical Research


Nuclear Medicine In Pharmaceutical Research
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Author : M. Frier
language : en
Publisher: CRC Press
Release Date : 2002-04-12

Nuclear Medicine In Pharmaceutical Research written by M. Frier and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-04-12 with Medical categories.


This text defines the role and scope of nuclear medicine imaging techniques (gamma scintigraphy) in pharmaceutical research, giving information from clinical trial data.

Advancing Nuclear Medicine Through Innovation


Advancing Nuclear Medicine Through Innovation
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2007-09-11

Advancing Nuclear Medicine Through Innovation written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-09-11 with Medical categories.


Nearly 20 million nuclear medicine procedures are carried out each year in the United States alone to diagnose and treat cancers, cardiovascular disease, and certain neurological disorders. Many of the advancements in nuclear medicine have been the result of research investments made during the past 50 years where these procedures are now a routine part of clinical care. Although nuclear medicine plays an important role in biomedical research and disease management, its promise is only beginning to be realized. Advancing Nuclear Medicine Through Innovation highlights the exciting emerging opportunities in nuclear medicine, which include assessing the efficacy of new drugs in development, individualizing treatment to the patient, and understanding the biology of human diseases. Health care and pharmaceutical professionals will be most interested in this book's examination of the challenges the field faces and its recommendations for ways to reduce these impediments.

Radionuclide Imaging In Drug Research


Radionuclide Imaging In Drug Research
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Author : Clive G. Wilson
language : en
Publisher: Springer
Release Date : 2012-04-22

Radionuclide Imaging In Drug Research written by Clive G. Wilson and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-22 with Science categories.


The use of gamma-emitting radionuclides for diagnostic imaging in nuclear medicine has been established for many years. Sophisticated gamma ray detecting camera systems and computer links enable the clinical investigator to image different regions of the body and to quantify organ function. Parallel developments have also occurred in the field of radiopharmaceuticals, and today a wide range of products is available that will exhibit specific uptake within target tissues following parenteral administration. For example, radioiodide is taken up by the thyroid and iodinated fatty acids can be used to image the myocardium. Labelled antibodies have been used with success to target certain tumours. The concept of targeting has also been considered by pharmaceutical scientists who wish to deliver drugs rather than radionuclides to specific sites in the body. The systems that have been employed are often physically similar to those used as radiopharmaceuticals (for example colloids, aerosols and liposomes). Furthermore, pioneering work by Digenis and others in the United States States and by Alpsten and co-workers (1976)in Sweden had demonstrated the potential of gamma scintigraphy for investigating the fate of tablets and capsules in the gastrointestinal tract of man in a non invasive way. In 1979, the Biopharmaceutics Research Group at Nottingham together with academic pharmacists from Manchester held a one-day syffiposium at Nottingham University to discuss how radio nuclides could be used in drug formulation studies to provide better approaches for the delivery of drugs to their sitesof action.

Technetium 99m Pharmaceuticals


Technetium 99m Pharmaceuticals
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Author : Ilse Zolle
language : en
Publisher: Springer
Release Date : 2006-11-07

Technetium 99m Pharmaceuticals written by Ilse Zolle and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-11-07 with Medical categories.


Radioactive drug development is a multi-disciplinary task. Therefore, dedicated scientists and experts from different fields of specialisation have contributed to this book. The text reviews forty years of advances in radiopharmaceutical development based on Technetium. The first section reviews basic principles and analytic methods, and information on chemical makeup of radiopharmaceuticals. Part 2 reviews 99mTc-radiopharmaceuticals used in nuclear medicine, thoroughly outlining their chemistry, formulation, pharmacokinetics and clinical applications.

Synthesis And Applications Of Isotopically Labelled Compounds


Synthesis And Applications Of Isotopically Labelled Compounds
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Author : Ulrich Pleiss
language : en
Publisher: John Wiley & Sons Incorporated
Release Date : 2001-03-28

Synthesis And Applications Of Isotopically Labelled Compounds written by Ulrich Pleiss and has been published by John Wiley & Sons Incorporated this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-03-28 with Science categories.


This outstanding book covers the most recent advances in the production of stable and radioactive isotopes as well as in the synthesis, analysis and applications of isotopically labelled compounds. Written by internationally renowned contributors, it provides authoritative and wide-ranging coverage of significant growth areas including: * new methodologies in the production of isotopes * novel approaches to compounds labelled with isotopes of hydrogen, carbon and other stable, long-lived and short-lived radioactive isotopes * advances in the analysis of istopically labelled compounds * recent and future applications of isotopes in pharmaceutical research and development, in pharmacological and clinical sutdies and nuclear medicine, as well as in agricultural, nutritional and environmental research * recent applications of isotopes in investigating organic and bioorganic mechanisms and pathways * safety and regulations of handling isotopes This will be an invaluable information and reference source to anyone involved in the production of isotopes, the synthesis and analysis of compounds labelled with stable, long-lived or short-lived radioactive isotopes, in drug research and development, in clinical investigations and nuclear medicine, in agricultural research and development and environmental investigations, in the elucidation of biological and chemical pathways, handling radioisotopes, laboratory design and other areas.

Radiopharmaceutical Chemistry


Radiopharmaceutical Chemistry
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Author : Jason S. Lewis
language : en
Publisher: Springer
Release Date : 2019-04-02

Radiopharmaceutical Chemistry written by Jason S. Lewis and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-02 with Medical categories.


This book is a comprehensive guide to radiopharmaceutical chemistry. The stunning clinical successes of nuclear imaging and targeted radiotherapy have resulted in rapid growth in the field of radiopharmaceutical chemistry, an essential component of nuclear medicine and radiology. However, at this point, interest in the field outpaces the academic and educational infrastructure needed to train radiopharmaceutical chemists. For example, the vast majority of texts that address radiopharmaceutical chemistry do so only peripherally, focusing instead on nuclear chemistry (i.e. nuclear reactions in reactors), heavy element radiochemistry (i.e. the decomposition of radioactive waste), or solely on the clinical applications of radiopharmaceuticals (e.g. the use of PET tracers in oncology). This text fills that gap by focusing on the chemistry of radiopharmaceuticals, with key coverage of how that knowledge translates to the development of diagnostic and therapeutic radiopharmaceuticals for the clinic. The text is divided into three overarching sections: First Principles, Radiochemistry, and Special Topics. The first is a general overview covering fundamental and broad issues like “The Production of Radionuclides” and “Basics of Radiochemistry”. The second section is the main focus of the book. In this section, each chapter’s author will delve much deeper into the subject matter, covering both well established and state-of-the-art techniques in radiopharmaceutical chemistry. This section will be divided according to radionuclide and will include chapters on radiolabeling methods using all of the common nuclides employed in radiopharmaceuticals, including four chapters on the ubiquitously used fluorine-18 and a “Best of the Rest” chapter to cover emerging radionuclides. Finally, the third section of the book is dedicated to special topics with important information for radiochemists, including “Bioconjugation Methods,” “Click Chemistry in Radiochemistry”, and “Radiochemical Instrumentation.” This is an ideal educational guide for nuclear medicine physicians, radiologists, and radiopharmaceutical chemists, as well as residents and trainees in all of these areas.

Pet For Drug Development And Evaluation


Pet For Drug Development And Evaluation
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Author : D. Comar
language : en
Publisher: Springer
Release Date : 2012-10-13

Pet For Drug Development And Evaluation written by D. Comar and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-13 with Medical categories.


Can drug development and evaluation be improved by the use of positron emission tomography (PET)? PET is now well established and many PET centres participate in networks that warrant the quality of their research. PET allows one to follow the effect of a drug on a variety of patients' metabolic parameters. In addition, PET may be used to follow the fate in vivo of a compound, allowing visualisation of its binding to specific receptors and a direct study of the mechanism of drug action in normal and pathological situations. The book shows the fields in which PET offers new and unique information for the development of drugs (conception, toxicity, pharmacokinetics and metabolism, clinical research, and relations between clinical and biological effects) and evaluates fields in which PET may shorten the development time of drugs. Audience: Professionals in the pharmaceutical industry in all areas of drug discovery and pharmacology, pre-clinical testing, pharmacokinetics and metabolism, clinical evaluation, registration and regulatory affairs. Government health authority representatives who assess data and documentation on new drug development and radiopharmaceuticals. Academic experts concerned with any of these areas.