Insulin Resistance And Insulin Resistance Syndrome

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Insulin Resistance And Insulin Resistance Syndrome


Insulin Resistance And Insulin Resistance Syndrome
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Insulin Resistance And Insulin Resistance Syndrome


Insulin Resistance And Insulin Resistance Syndrome
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Author : Barbara Hansen
language : en
Publisher: CRC Press
Release Date : 2013-08-29

Insulin Resistance And Insulin Resistance Syndrome written by Barbara Hansen and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-29 with Medical categories.


Type II diabetes has developed into a global epidemic, with nearly 20 type II patients for every type I individual. Preceding the onset of type II diabetes is a prolonged episode of insulin resistance featuring a host of detrimental symptoms. This period comprises a disease referred to as Insulin Resistance Syndrome or Metabolic Syndrome. In

Insulin Resistance


Insulin Resistance
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Author : Philip Scott Zeitler
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-12-28

Insulin Resistance written by Philip Scott Zeitler and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-28 with Medical categories.


In the mid 1990s, Drs. Gerald Reaven identified a constellation of clinical findings, known variously as the metabolic syndrome, syndrome X, insulin resistance s- drome or insulin resistance-related disorders, that are associated with an increased risk of heart disease and diabetes. Interest in this topic grew rapidly, culminating in the publication by this series of the book, Insulin Resistance and the Metabolic Syndrome X, edited by Drs. Reaven and Laws in 1999. Since the original publication of that now classic volume, the world’s population has continued to become more obese and sedentary and the prevalence of disorders related to insulin resistance has continued to increase throughout the developed and developing world. Of great concern in the last decade is the extension of these deleterious lifestyle patterns to the pediatric population, leading to both obesity and the appearance of insulin resistance-related disorders in youth as well as adults. Today, about one in three children and adolescents in the United States is overweight or obese, and this prevalence approaches one in two among adolescents in certain minority groups. In addition, components of this cardiovascular risk constellation are now being recognized in young adults, adolescents, and even children. Youth are increasingly developing type 2 diabetes, fatty liver disease, hypertriglyceridemia, hypertension, polycystic ovarian syndrome, sleep apnea, orthopedic and psychiatric complications, as well as other complications of obesity and insulin resistance.

Insulin Resistance


Insulin Resistance
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Author : Gerald M. Reaven
language : en
Publisher: Springer Science & Business Media
Release Date : 1999-04

Insulin Resistance written by Gerald M. Reaven and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-04 with Medical categories.


In Insulin Resistance: The Metabolic Syndrome X, outstanding investigators thoughtfully summarize our current understanding of how insulin resistance and its compensating hyperinsulinemia (Syndrome X) play a major role in the pathogenesis and clinical course of high blood pressure and cardiovascular disease-the so-called diseases of Western civilization-as well as polycystic ovary disease. Under the aegis of Gerald Reaven, the discoverer of Syndrome X, the distinguished authorities writing here detail for the first time the pathophysiological consequences and the clinical syndromes, excluding Type 2 diabetes, related to insulin resistance. They also examine the genetic and lifestyle factors that contribute to the wide differences in insulin action that exist in the population at large. Each author has been encouraged to present a point of view that reflects their unique insights. The first authoritative book on the subject, Insulin Resistance: The Metabolic Syndrome X illuminates the special importance of insulin resistance as a major cause of hypertension, heart disease, and polycystic ovary syndrome. Its thoughtful and detailed approach will make it an essential reference for basic and clinical researchers seeking to understand these critical phenomena.

Insulin Resistance


Insulin Resistance
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Author : Sudhesh Kumar
language : en
Publisher: John Wiley & Sons
Release Date : 2005-07-15

Insulin Resistance written by Sudhesh Kumar and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-07-15 with Medical categories.


Diabetes is now one of the major causes of morbidity worldwide. In many cases, the onset of diabetes is progressive, developing via a condition of insulin resistance. This book considers the development of this condition, its consequences and clinical and therapeutic aspects. The book reviews the normal biology of insulin action on glucose, lipids and proteins. It considers the pathological basis for insulin resistance in animal models and humans, and discusses the influence of heredity, dietary factors and exercise. Clinical consequences including dyslipidaemia, hypertension and polycystic ovary syndrome, and therapeutic strategies for treatment are also examined. * Provides an expert review of the phenomenon of insulin resistance * Brings together a host of recent research for the first time * Written by leading experts in biological and clinical research

Understanding Insulin And Insulin Resistance


Understanding Insulin And Insulin Resistance
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Author : Anil Gupta
language : en
Publisher: Elsevier
Release Date : 2021-11-26

Understanding Insulin And Insulin Resistance written by Anil Gupta and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Medical categories.


Understanding Insulin and Insulin Resistance is written in simple, clear language with diagrams that show the complex interplay of various factors in the initiation of insulin resistance. The design is systematic and meticulous, portraying topics in a flow from simple to complex. This resource is intended for a broad audience spanning across biochemistry, medicine, dentistry, academia, physicians, and research scholars. It extends the approach to biochemistry, physiology, metabolism of insulin along with the coverage of pathophysiology of insulin resistance, its effects on the body tissues, and its analysis on insulin resistance syndrome. Combines both intensive and extensive study material related to the topic Describes insulin resistance syndrome encompassing details regarding its prevalence and components Blends both theoretical and clinical knowledge related to insulin and insulin resistance syndrome Gathers the vast knowledge about insulin and insulin resistance in one volume, eliminating searches through hundreds of journal articles

Insulin Resistance Ecab


Insulin Resistance Ecab
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Author : Gita Ganguly Mukherjee
language : en
Publisher: Elsevier Health Sciences
Release Date : 2012-06-07

Insulin Resistance Ecab written by Gita Ganguly Mukherjee and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-07 with Medical categories.


The insulin resistance syndrome can be defined as insulin resistance, compensatory hyperinsulinemia, and their associated co-morbidities. Clinically, the term insulin resistance syndrome describes a constellation of abnormalities such as obesity, hypertension, dyslipidemia, type 2 diabetes/hyperglycemia, and coronary artery disease. Insulin is responsible for glucose uptake into the body cells and tissues. The response of the cells to insulin varies from individual to individual. In some individuals, the tissue response to insulin may be diminished. This means that even with adequate levels of insulin, the glucose uptake into the cells and tissues is not optimal. This results in a compensatory over-secretion of insulin from the pancreas. The persistence of high levels of insulin in the blood or hyperinsulinemia is thought to be responsible for some of the abnormalities associated with this condition. However, the exact causal association of the condition with these disorders and the pathophysiology of their evolution are unclear. The most common underlying mechanism proposed is increased free fatty acids from abdominal fat in individuals with central obesity. This leads to deranged insulin signaling, reduced muscular glucose uptake, increased triglyceride synthesis, and hepatic gluconeogenesis. A genetic basis of the disease as well as several other factors such as tumor necrosis factor-α, adiponectin, leptin, Interleukin-6, and some adipokines have also been implicated. Insulin resistance syndrome is of clinical significance because of its association with potentially debilitating conditions that contribute to long-term morbidity and even mortality of the individual. People with insulin resistance syndrome are at an increased risk of developing type 2 diabetes, hypertension, dyslipidemia, myocardial infarction, polycystic ovarian disease, and fatty liver. In this book, we have tried to collate the experiences of the pioneers of this field on the subject and provide the reader a comprehensive view on the topic along with practical management points, which we are sure will benefit the physicians in their clinical practice. The contributors have focused on the condition as is prevalent in our subcontinent and have tried to give an insight on the issues pertaining to the same with a topical flavor.

Study Of Factors Regulating Metabolic Syndrome And Insulin Resistance


Study Of Factors Regulating Metabolic Syndrome And Insulin Resistance
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Author : Madlena A. Nalbandian
language : en
Publisher:
Release Date : 2013

Study Of Factors Regulating Metabolic Syndrome And Insulin Resistance written by Madlena A. Nalbandian and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.


Metabolic syndrome, also known as syndrome X and insulin resistance syndrome, is a global pandemic that has been exponentially increasing throughout the last two decades. Obesity and insulin resistance are the primary components of metabolic syndrome. Our study aimed to identify factors regulating insulin resistance by further increasing our knowledge of 12/15 lipoxygenase along with a implementing a dietary intervention to reduce insulin resistance. We tested the hypothesis that 12/15 lipoxygenase transgenic mice on a 45% HFD after 10 weeks would have significantly greater insulin resistance than the wildtype mice. We also hypothesized that a dietary intervention with low glycemic index bread products along with omega-3 and polyphenol supplements for 12 weeks should decrease insulin resistance and lower the risk of developing chronic diseases more effectively than a placebo-controlled diet. The 12/15-lipoxygenase mice study showed that the 12/15 lipoxygenase transgenic mice had significantly higher fasting plasma glucose concentrations, fasting insulin concentrations, plasma triglyceride concentration, and greater gWAT percentage of body weight compared to the wildtype mice. The study also suggested that the 12/15-lipoxygenase mice had greater systemic insulin resistance than the wildtype mice. The dietary intervention study, although incomplete at this stage, showed trends for enhanced insulin sensitivity with the active diet, body weight loss, fat mass loss, waist circumference decrease and improvements in lipid panel were significant in both diet groups. These studies shed new light on mechanisms regulating insulin resistance.