Ebola And Marburg Viruses Replicate In Monocyle Derived Dendritic Cells Without Inducing The Production Of Cytokines And Full Maturation

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Ebola And Marburg Viruses Replicate In Monocyle Derived Dendritic Cells Without Inducing The Production Of Cytokines And Full Maturation


Ebola And Marburg Viruses Replicate In Monocyle Derived Dendritic Cells Without Inducing The Production Of Cytokines And Full Maturation
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Ebola And Marburg Viruses Replicate In Monocyle Derived Dendritic Cells Without Inducing The Production Of Cytokines And Full Maturation


Ebola And Marburg Viruses Replicate In Monocyle Derived Dendritic Cells Without Inducing The Production Of Cytokines And Full Maturation
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Author :
language : en
Publisher:
Release Date : 2003

Ebola And Marburg Viruses Replicate In Monocyle Derived Dendritic Cells Without Inducing The Production Of Cytokines And Full Maturation written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with categories.


Ebola virus (EBOV) and Marburg virus (MARV) cause rapidly progressive hemorrhagic fever with high mortality and may possess specialized mechanisms to evade immune destruction. We postulated that immune evasion could be due to the ability of EBOV and MARV to interfere with dendritic cells (DCs), which link innate and adaptive immune responses. We demonstrate that EBOV and MARV infected and replicated in primary human DCs without inducing cytokine secretion. Infected DC cultures supported exponential viral growth without releasing interferon (IFN)-alpha and were impaired in IFN-alpha production if treated with double-stranded RNA. Moreover, EBOV and MARV impaired the ability of DCs to support T cell proliferation, and infected, immature DCs underwent an anomalous maturation. These findings may explain the profound virulence of EBOV and MARV-DCs are disabled, and an effective early host response is delayed by the necessary reliance on less-efficient secondary mechanisms.

Ebola And Marburg Viruses


Ebola And Marburg Viruses
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Author : Hans-Dieter Klenk
language : en
Publisher: Garland Science
Release Date : 2004

Ebola And Marburg Viruses written by Hans-Dieter Klenk and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Science categories.


The Ebola and Marburg viruses are a pair of filoviruses that are among the most lethal hemorrhagic viruses on the planet. The authors present a review of past and current research into these pathogens, including 12 papers addressing the structure of the viral proteins; genomic replication; molecular mechanisms of entry; pathogenesis in nonhuman primates, guinea pigs, and mice; virus modulation of innate immunity; and cellular and molecular mechanisms of Ebola pathogenicity and related approaches to vaccine development.

Biology And Pathogenesis Of Rhabdo And Filoviruses


Biology And Pathogenesis Of Rhabdo And Filoviruses
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Author : Asit K Pattnaik
language : en
Publisher: World Scientific
Release Date : 2014-12-30

Biology And Pathogenesis Of Rhabdo And Filoviruses written by Asit K Pattnaik and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-30 with Science categories.


Rhabdoviruses and Filoviruses are single-stranded, non-segmented, negative-strand RNA viruses, many of which cause significant morbidity and mortality in humans and animals. Certain members of these virus families have been used as excellent model systems to understand the molecular biology of replication, host responses to infections, and viral countermeasures. Rhabdoviruses have also been used as vaccine vectors as well as oncolytic agents. Studies on Filoviruses have now provided significant insights into how they enter susceptible cells, replicate and cause disease, and also how they evade the host's immune mechanisms. This book addresses the most recent findings on Rhabdovirus and Filovirus structure, replication mechanisms, host cell responses to virus infections and viral countermeasures. Chapters on emerging viruses as well as approaches for therapeutic interventions have also been included. This book represents an authoritative text that brings together the most recent advances on the cellular and molecular biology of Rhabdo- and Filoviruses, including mechanisms of pathogenesis. Contents:Overview of Rhabdo– and Filoviruses (Asit K Pattnaik and Michael A Whitt)Rhabdovirus Structure (Ming Luo)The Pathway of VSV Entry into Cells (Shem Johnson and Jean Gruenberg)Rhabdovirus Glycoproteins (Yves Gaudin and Michael A Whitt)VSV RNA Transcription and Replication (Jacques Perrault)Host Cell Functions in Vesicular Stomatitis Virus Replication (Phat X Dinh, Anshuman Das, and Asit K Pattnaik)Cytopathogenesis of Rhabdoviruses (Douglas S Lyles)Assembly and Budding of Rhabdo– and Filoviruses (Ziying Han and Ronald N Harty)Rhabdoviruses as Vaccine Vectors: From Initial Development to Clinical Trials (John K Rose and David K Clarke)Oncolytic Rhabdoviruses (Nicole E Forbes and John C Bell)Use of Rhabdoviruses to Study Neural Circuitry (Melanie Ginger, Guillaume Bony, Matthias Haberl, and Andreas Frick)Evolution of Rhabdo– and Filoviruses (Isabel S Novella, John B Presloid, and R Travis Taylor)Emerging Rhabdoviruses (Imke Steffen and Graham Simmons)Rabies Virus Replication and Pathogenesis (Andrew W Hudacek and Matthias J Schnell)Activation and Evasion of Innate Immune Response by Rhabdoviruses (Karl-Klaus Conzelmann)Rabies Virus Vaccines (Ying Huang, Clement W Gnanadurai, and Zhen F Fu)Filovirus Structure and Morphogenesis (Timothy F Booth, Daniel R Beniac, Melissa J Rabb, and Lindsey L Lamboo)Epidemiology and Pathogenesis of Filovirus Infections (Logan Banadyga and Hideki Ebihara)Filovirus Entry into Susceptible Cells (Rohit K Jangra, Eva Mittler, and Kartik Chandran)Filovirus Transcription & Replication (Kristina Brauburger, Laure R Deflubé, and Elke Muhlberger)Innate Immune Evasion Mechanisms of Filoviruses (Christopher F Basler, Gaya K Amarasinghe, and Daisy W Leung)Vaccines and Antivirals for Filoviruses (Chad E Mire and Thomas W Geisbe) Readership: Investigators, graduate students, and post-graduate researchers in the field of RNA virology. Key Features:The book describes the most recent advances in our understanding of cellular and molecular aspects of replication and pathogenic mechanisms of these two important viral pathogensUnlike other existing textbooks published earlier, this book brings together several major topics of research such as replication, host response to viral replication and viral countermeasures, viral evolution and emerging viruses, viral vectors, vaccines and antivirals, etcThe chapters in the book are written by renowned researchers in these fieldsKeywords:Negative-Strand RNA Virus;Mononegavirales;Rhabdovirus;Filovirus;VSV;Rabies Virus;Marburg Virus;Ebola Virus;Replication and Transcription;Virus Structure;Viral Pathogenesis;Epidemiology;Virus Entry;Virus Assembly and Budding;Cytopathogenesis;Neuronal Tracers;Viral Vectors;Oncolytic Viruses;Evolution;Emerging Viruses;Innate Immune Responses;Vaccines;Antivirals

Modulation Of Host Gene Expression And Innate Immunity By Viruses


Modulation Of Host Gene Expression And Innate Immunity By Viruses
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Author : Peter Palese
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-07-11

Modulation Of Host Gene Expression And Innate Immunity By Viruses written by Peter Palese and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-07-11 with Science categories.


This book is an excellent, up-to-date reference on a relatively young area of research in which virology, cellular biology and molecular pathogenesis govern the principles of coinvestigation. Thus, the book will be of great interest to virologists, molecular immunologists and biologists, and biochemists but also to clinical pharmacologists in the long-term search for new antiviral agents. Ulrich Desselberger, Gif-sur-Yvette/Cambridge. Infection of a naïve (non-immune) host with a virus elicits an immediate response which results in a cascade of changes in the host, including an interferon response (innate immunity). The outcome of this interaction is influenced by the genes of the virus as well as the genes of the host. Interestingly, different viruses do it in different ways. Not only is there a plethora of mechanisms used by the invading organisms, but the host has also evolved a great variety of redundant and robust countermeasures. This interplay of host and virus represents one of the most significant frontiers in biology today. A clearer understanding of the mechanisms involved will arm us with better strategies to deal with viruses, including emerging pathogens and potential bioterrorism agents. This book is sure to benefit students, scientists, and physicians working in the areas of virology, immunology, microbiology, and infectious diseases. Pharmaceutical industry professionals will also find interest in this illuminating look into virus/host interactions.

Manual Of Security Sensitive Microbes And Toxins


Manual Of Security Sensitive Microbes And Toxins
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Author : Dongyou Liu
language : en
Publisher: CRC Press
Release Date : 2014-04-08

Manual Of Security Sensitive Microbes And Toxins written by Dongyou Liu and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-08 with Medical categories.


Security sensitive microbes (viruses, bacteria, fungi, and parasites) and toxins, which are often referred to as the select agents and toxins, have the capacity to cause serious illness and death in humans, animals, and plants. Throughout history, these microbes and toxins have been exploited in one form or another as biowarfare and bioterror agents that create fear and panic well beyond any actual physical damages they might cause. Manual of Security Sensitive Microbes and Toxins provides comprehensive, state-of-the-art coverage of microbes and toxins of biosecurity concern. The ultimate goal is to increase our awareness of these agents and enhance our preparedness against any future bio-emergencies. The book begins with an introduction containing a brief overview of the historical aspects of security sensitive microbes and toxins. This is followed by a concise summary of the current status in relation to the regulation of security sensitive microbes and toxins and a discussion of future development trends. The book is divided into seven parts: Microbes and Toxins Affecting Humans and Animals: Viruses Microbes and Toxins Affecting Human and Animals: Bacteria Microbes and Toxins Affecting Human and Animals: Fungus and Parasite Microbes and Toxins Affecting Human and Animals: Toxins Microbes Affecting Animals: Viruses Microbes Affecting Animals: Bacteria Microbes Affecting Plants Written by experts in the relevant areas of research, the chapters are authoritative reviews, each one covering a single microbe or toxin with respect to its classification, biology, epidemiology, pathogenesis, identification, diagnosis, treatment, and prevention. The chapters also discuss the limitations of our current knowledge and challenges relating to improved detection and control of the microbe or toxin.

Molecular Pathogenesis Of Virus Infections


Molecular Pathogenesis Of Virus Infections
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Author : Society for General Microbiology. Symposium
language : en
Publisher: Cambridge University Press
Release Date : 2005-04-21

Molecular Pathogenesis Of Virus Infections written by Society for General Microbiology. Symposium and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-04-21 with Medical categories.


Virus and prion diseases remain a major public health threat, in both developed and developing countries. The worldwide HIV pandemic is one example of a newly emerged virus diseases, and older human viruses such as influenza, papilloma, and the hepatitis viruses still cause major health problems. Some viruses may also establish persistent infections which can lead to the development of chronic diseases, including cancer. This symposium book covers the central factors that influence the pathogenicity of virus and prion infections.

Feigin And Cherry S Textbook Of Pediatric Infectious Diseases E Book


Feigin And Cherry S Textbook Of Pediatric Infectious Diseases E Book
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Author : James Cherry
language : en
Publisher: Elsevier Health Sciences
Release Date : 2013-10-05

Feigin And Cherry S Textbook Of Pediatric Infectious Diseases E Book written by James Cherry and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-05 with Medical categories.


Feigin and Cherry's Textbook of Pediatric Infectious Diseases helps you put the very latest knowledge to work for your young patients with unparalleled coverage of everything from epidemiology, public health, and preventive medicine through clinical manifestations, diagnosis, treatment, and much more. Ideal for all physicians, whether in an office or hospital setting, Feigin and Cherry’s equips you with trusted answers to your most challenging clinical infectious disease questions. Meet your most difficult clinical challenges in pediatric infectious disease, including today’s more aggressive infectious and resistant strains as well as emerging and re-emerging diseases, with unmatched, comprehensive coverage of immunology, epidemiology, public health, preventive medicine, clinical manifestations, diagnosis, treatment, and much more. Find the answers you need quickly thanks to an organization both by organ system and by etiologic microorganism, allowing you to easily approach any topic from either direction.